Isabel wrote and directed three features, including Señorita and Apparition. Her third feature Lingua Franca premiered at the 2019 Venice International Film Festival making her the first transgender director to compete at the festival. Her films have also been programmed at the BFI London, Vancouver, Stockholm, Hamburg, Goteborg, Thessaloniki, AFI Fest and Palm Springs. Last November, she was awarded the prestigious SFFILM Westridge Foundation screenwriting grant for her new dramatic feature, Baptism. The Museum of Modern Art has recognized her as a “rarity among the young generation of Filipino filmmakers.